Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell
Résumé
Heteromeric nicotinic receptors assemble alpha and beta subunits in pentameric structures, which can adopt two stoichiometries: 3:2
or 2alpha:3beta. Both stoichiometric variants are present in the CNS, but they have never been located and characterized functionally at
the level of an identified synapse. Our data indicate that 3alpha:2beta receptors are present at the spinal cord synapses between motoneurons
and Renshaw cells, where their dual mode of activation (by high concentrations of ACh for synaptic receptors, by low
concentrations of ACh for extrasynaptic receptors) likely accounts for the biphasic character of the synaptic current. More
generally, 3alpha:2beta nicotinic receptors appear unique by their capacity to operate both in the cleft of classical synapses and at
extrasynaptic locations.
Domaines
Sciences du Vivant [q-bio]
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d'Incamps et al. - 2018 - Stoichiometry of the Heteromeric Nicotinic Recepto.pdf (2.71 Mo)
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