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Communication Dans Un Congrès Année : 2019

Assessment of two T1D components within myelinated tissue with ihMT MRI

Résumé

T1D, the relaxation time of the dipolar order, is a probe for membrane dynamics and organization that could be used to assess myelin integrity. A single-component T1D model associated with a modified ihMT sequence had been proposed for in vivo evaluation of T1D with MRI. However, experiments and simulations revealed that myelinated tissues exhibit multiple T1D components. A bi-component T1D model is proposed and validated. Fits in a rat spinal cord yield two T1Ds of about 10 ms and 400 μs. The results suggest that myelin has a dynamically heterogeneous organization.
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Dates et versions

hal-02371984 , version 1 (20-11-2019)

Identifiants

  • HAL Id : hal-02371984 , version 1

Citer

Victor Carvalho, Olivier M. Girard, Andreea Hertanu, Samira Mchinda, Lucas Soustelle, et al.. Assessment of two T1D components within myelinated tissue with ihMT MRI. Proc. Intl. Soc. Mag. Reson. Med. 27, May 2019, Montreal, Canada. pp.4915. ⟨hal-02371984⟩
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