Identification and investigation of the vibrational properties of crystalline and co-amorphous drugs with Raman and terahertz spectroscopy - CNRS - Centre national de la recherche scientifique
Article Dans Une Revue Biomedical optics express Année : 2019

Identification and investigation of the vibrational properties of crystalline and co-amorphous drugs with Raman and terahertz spectroscopy

Résumé

Co-amorphous drugs have shown significant potential in improving the stability and bioavailability compared with single neat amorphous drugs. Here, we explored the molecular interactions of cimetidine, naproxen, indomethacin and their binary co-amorphous mixtures via Raman and terahertz (THz) spectroscopy. We used quench-cooled method to prepare the neat amorphous drugs and their binary co-amorphous mixtures and tested their thermodynamic properties through differential scanning calorimetry (DSC). Then, we found that the stability of co-amorphous drugs was stronger than their neat amorphous components. Furthermore, Raman spectroscopy was used to characterize the vibrational modes between different co-amorphous drugs. Generally, we found that the stability of co-amorphous drugs was better than their neat amorphous components for these samples we tested. Meanwhile, we complemented the detection of THz spectroscopy and found that crystalline and amorphous drugs could be better distinguished.

Dates et versions

hal-02445512 , version 1 (20-01-2020)

Identifiants

Citer

Wei Liu, Yu Liu, Jiaoqi Huang, Zhongquan Lin, Xuancheng Pan, et al.. Identification and investigation of the vibrational properties of crystalline and co-amorphous drugs with Raman and terahertz spectroscopy. Biomedical optics express, 2019, 10 (8), pp.4290-4304. ⟨10.1364/BOE.10.004290⟩. ⟨hal-02445512⟩
46 Consultations
0 Téléchargements

Altmetric

Partager

More