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Article Dans Une Revue Angewandte Chemie International Edition Année : 2019

Parallel homochiral and anti-parallel heterochiral hydrogen-bonding interfaces in multi-helical abiotic foldamers

Résumé

A hydrogen-bonding interface between helical aromatic oligoamide foldamers has been designed to promote the folding of a helix-turn-helix motif with a head-to-tail arrangement of two helices of opposite handedness. This design complements an earlier helix-turn-helix motif with a head-to-head arrangement of two helices of identical handedness interface. The two motifs were shown to have comparable stability and were combined in a unimolecular tetra-helix fold constituting the largest abiotic tertiary structure to date.

Domaines

Matériaux

Dates et versions

hal-02569715 , version 1 (11-05-2020)

Identifiants

Citer

Daniela Mazzier, Soumen De, Barbara Wicher, Victor Maurizot, Ivan Huc. Parallel homochiral and anti-parallel heterochiral hydrogen-bonding interfaces in multi-helical abiotic foldamers. Angewandte Chemie International Edition, In press, 59 (4), pp.1606-1610. ⟨10.1002/anie.201912805⟩. ⟨hal-02569715⟩

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