Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer
Résumé
Highlights d Pancreatic ductal adenocarcinoma (PDAC) displays OXPHOS heterogeneity d High OXPHOS PDAC tumors are enriched in mitochondrial respiratory complex I d Complex I inhibitor phenformin synergizes with chemotherapy in high OXPHOS cells d Phenformin cooperates with gemcitabine antitumoral activity in high OXPHOS tumors
Domaines
Sciences du Vivant [q-bio]Origine | Publication financée par une institution |
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