Chronology of natural selection in Oceanian genomes - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue iScience Année : 2022

Chronology of natural selection in Oceanian genomes

Résumé

As human populations left Asia to first settle in Oceania around 50,000 years ago, they entered a territory ecologically separated from the Old World for millions of years. We analyzed genomic data of 239 modern Oceanian individuals to detect and date signals of selection specific to this region. Combining both relative and absolute dating approaches, we identified a strong selection pattern between 52,000 and 54,000 years ago in the genomes of descendants of the first settlers of Sahul. This strikingly corresponds to the dates of initial settlement as inferred from archaeological evidence. Loci under selection during this period, some showing enrichment in Denisovan ancestry, overlap genes involved in the immune response and diet, especially based on plants. Pathogens and natural resources, especially from endemic plants, therefore appear to have acted as strong selective pressures on the genomes of the first settlers of Sahul
Fichier principal
Vignette du fichier
ISCI_104583_edit_report - Copie.pdf (604.55 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03753678 , version 1 (18-08-2022)

Identifiants

Citer

Nicolas Brucato, Mathilde André, Georgi Hudjashov, Mayukh Mondal, Murray Cox, et al.. Chronology of natural selection in Oceanian genomes. iScience, 2022, 25 (7), pp.104583. ⟨10.1016/j.isci.2022.104583⟩. ⟨hal-03753678⟩
88 Consultations
28 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More