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Article Dans Une Revue Progress in Neurobiology Année : 2022

Altered activity-regulated H3K9 acetylation at TGF-beta signaling genes during egocentric memory in Huntington's disease

Résumé

Molecular mechanisms underlying cognitive deficits in Huntington's disease (HD), a striatal neurodegenerative disorder, are unknown. Here, we generated ChIPseq, 4Cseq and RNAseq data on striatal tissue of HD and control mice during striatum-dependent egocentric memory process. Multiomics analyses showed altered activity-dependent epigenetic gene reprogramming of neuronal and glial genes regulating striatal plasticity in HD mice, which correlated with memory deficit. First, our data reveal that spatial chromatin reorganization and transcriptional induction of BDNF-related markers, regulating neuronal plasticity, were reduced since memory acquisition in the striatum of HD mice. Second, our data show that epigenetic memory implicating H3K9 acetylation, which established during late phase of memory process (e.g. during consolidation/recall) and contributed to gliamediated, TGF-dependent plasticity, was compromised in HD mouse striatum. Specifically, memorydependent regulation of H3K9 acetylation was impaired at genes controlling extracellular matrix and myelination. Our study investigating the interplay between epigenetics and memory identifies H3K9 acetylation and TGF signaling as new targets of striatal plasticity, which might offer innovative leads to improve HD.

Dates et versions

hal-03853139 , version 1 (15-11-2023)

Identifiants

Citer

Rafael Alcalá-Vida, Caroline Lotz, Baptiste Brulé, Jonathan Seguin, Charles Decraene, et al.. Altered activity-regulated H3K9 acetylation at TGF-beta signaling genes during egocentric memory in Huntington's disease. Progress in Neurobiology, 2022, 219, pp.102363. ⟨10.1016/j.pneurobio.2022.102363⟩. ⟨hal-03853139⟩
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