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Journal Articles (Review Article) Current Opinion in Cell Biology Year : 2023

The compass to follow: focal adhesion turnover


How cells move is a fundamental biological question. The directionality of adherent migrating cells depends on the assembly and disassembly (turnover) of focal adhesions (FAs). FAs are micron-sized actin-based structures that link cells to the extracellular matrix. Traditionally, microtubules have been considered key to triggering FA turnover. Through the years, advancements in biochemistry, biophysics, and bioimaging tools have been invaluable for many research groups to unravel a variety of mechanisms and molecular players that contribute to FA turnover, beyond microtubules. Here we discuss recent discoveries of key molecular players that affect the dynamics and organization of the actin cytoskeleton to enable timely FA turnover and consequently proper directed cell migration.
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hal-03940281 , version 1 (16-01-2023)



Manos Mavrakis, Maria Angeles Juanes. The compass to follow: focal adhesion turnover. Current Opinion in Cell Biology, 2023, 80, pp.102152. ⟨10.1016/⟩. ⟨hal-03940281⟩
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