Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia - Archive ouverte HAL Access content directly
Journal Articles International Journal of Molecular Sciences Year : 2022

Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia

Baptiste Wilmet
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Jacques Callebert
Robert Duvoisin
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Ruben Goulet
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Christophe Tourain
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Christelle Michiels
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Helen Frederiksen
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Frank Schaeffel
Olivier Marre
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José Alain Sahel
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Isabelle Audo
Serge Picaud
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Christina Zeitz
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Abstract

Mutations in GPR179 are one of the most common causes of autosomal recessive complete congenital stationary night blindness (cCSNB). This retinal disease is characterized in patients by impaired dim and night vision, associated with other ocular symptoms, including high myopia. cCSNB is caused by a complete loss of signal transmission from photoreceptors to ON-bipolar cells. In this study, we hypothesized that the lack of Gpr179 and the subsequent impaired ONpathway could lead to myopic features in a mouse model of cCSNB. Using ultra performance liquid chromatography, we show that adult Gpr179 −/− mice have a significant decrease in both retinal dopamine and 3,4-dihydroxyphenylacetic acid, compared to Gpr179 +/+ mice. This alteration of the dopaminergic system is thought to be correlated with an increased susceptibility to lens-induced myopia but does not affect the natural refractive development. Altogether, our data added a novel myopia model, which could be used to identify therapeutic interventions.
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hal-03954423 , version 1 (24-01-2023)

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Baptiste Wilmet, Jacques Callebert, Robert Duvoisin, Ruben Goulet, Christophe Tourain, et al.. Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia. International Journal of Molecular Sciences, 2022, 24, ⟨10.3390/ijms24010219⟩. ⟨hal-03954423⟩
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