Galectin functions in cancer-associated inflammation and thrombosis - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Frontiers in Cardiovascular Medicine Année : 2023

Galectin functions in cancer-associated inflammation and thrombosis

Résumé

Galectins are carbohydrate-binding proteins that regulate many cellular functions including proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical evidence indicates that galectins influence many steps of cancer development by inducing the recruitment of immune cells to the inflammatory sites and modulating the effector function of neutrophils, monocytes, and lymphocytes. Recent studies described that different isoforms of galectins can induce platelet adhesion, aggregation, and granule release through the interaction with platelet-specific glycoproteins and integrins. Patients with cancer and/or deep-venous thrombosis have increased levels of galectins in the vasculature, suggesting that these proteins could be important contributors to cancer-associated inflammation and thrombosis. In this review, we summarize the pathological role of galectins in inflammatory and thrombotic events, influencing tumor progression and metastasis. We also discuss the potential of anti-cancer therapies targeting galectins in the pathological context of cancer-associated inflammation and thrombosis.

Domaines

Cancer
Fichier principal
Vignette du fichier
fcvm-10-1052959.pdf (2.69 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04021160 , version 1 (11-10-2023)

Identifiants

Citer

Linus Kruk, Attila Braun, Erika Cosset, Thomas Gudermann, Elmina Mammadova-Bach. Galectin functions in cancer-associated inflammation and thrombosis. Frontiers in Cardiovascular Medicine, 2023, 10, ⟨10.3389/fcvm.2023.1052959⟩. ⟨hal-04021160⟩
46 Consultations
5 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More