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Journal Articles International Journal of Radiation Oncology, Biology, Physics Year : 2023

Proton FLASH Radiation Therapy and Immune Infiltration: Evaluation in an Orthotopic Glioma Rat Model

Abstract

FLASH radiation therapy (FLASH-RT) is a promising radiation technique that uses ultrahigh doses of radiation to increase the therapeutic window of the treatment. FLASH-RT has been observed to provide normal tissue sparing at high dose rates and similar tumor control compared with conventional RT, yet the biological processes governing these radiobiological effects are still unknown. In this study, we sought to investigate the potential immune response generated by FLASH-RT in a high dose of proton therapy in an orthotopic glioma rat model.
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Dates and versions

hal-04237323 , version 1 (11-10-2023)

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Lorea Iturri, Annaïg Bertho, Charlotte Lamirault, Marjorie Juchaux, Cristèle Gilbert, et al.. Proton FLASH Radiation Therapy and Immune Infiltration: Evaluation in an Orthotopic Glioma Rat Model. International Journal of Radiation Oncology, Biology, Physics, 2023, 116 (3), pp.655-665. ⟨10.1016/j.ijrobp.2022.12.018⟩. ⟨hal-04237323⟩
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