Parental age effect on the longevity and healthspan in Drosophila melanogaster and Caenorhabditis elegans - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Aging Année : 2023

Parental age effect on the longevity and healthspan in Drosophila melanogaster and Caenorhabditis elegans

Résumé

Several studies have investigated the effect of parental age on biological parameters such as reproduction, lifespan, and health; however, the results have been inconclusive, largely due to inter-species variation and/or modest effect sizes. Here, we examined the effect of parental age on the lifespan, reproductive capacity, and locomotory activity of genetic isogenic lines of the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster. We found that the progeny of successive generations of old parents had significantly shorter lifespans than the progeny of young parents in both species. Moreover, we investigated the fertility, fecundity, and locomotory activity of C. elegans. Interestingly, both the shorter lifespan and deteriorated healthspan of the progeny were significantly improved by switching to only one generation of younger parents. Collectively, these data demonstrate that the detrimental effect of older parental age on the longevity of the progeny can be reversed, suggesting the existence of a beneficial non–genetic mechanism.
Fichier principal
Vignette du fichier
aging-v15-205098_LAST.pdf (2.18 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Licence : CC BY - Paternité

Dates et versions

hal-04244438 , version 1 (16-10-2023)

Licence

Paternité

Identifiants

Citer

Camille Lenzi, Alexis Piat, Pascal Schlich, Judith Ducau, Jean-Claude Bregliano, et al.. Parental age effect on the longevity and healthspan in Drosophila melanogaster and Caenorhabditis elegans. Aging, 2023, 15 (21), pp.11720—11739. ⟨10.18632/aging.205098⟩. ⟨hal-04244438⟩
42 Consultations
52 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More