Molecular Diversity of Cyclooctatetraenes through Palladium-Catalyzed Cascade Reactions
Résumé
We report a cascade reaction leading to fully substituted cyclooctatetraenes. This transformation likely proceeds through a double cyclocarbopalladation, a unique 8-electrocyclization and ends by either a Stille, Sonogashira or Suzuki-Miyaura cross coupling. Structural modifications of the starting material were investigated to identify their effects on the reaction and extend the structural diversity possible through this transformation.
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