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Article Dans Une Revue Clinical Cancer Research Année : 2017

Molecular Pathways: The eIF4F Translation Initiation Complex—New Opportunities for Cancer Treatment

Résumé

The eIF4F complex regulates the cap-dependent mRNA translation process. It is becoming increasingly evident that aberrant activity of this complex is observed in many cancers, leading to the selective synthesis of proteins involved in tumor growth and metastasis. The selective translation of cellular mRNAs controlled by this complex also contributes to resistance to cancer treatments, and downregulation of the eIF4F complex components can restore sensitivity to various cancer therapies. Here, we review the contribution of the eIF4F complex to tumorigenesis, with a focus on its role in chemoresistance as well as the promising use of new small-molecule inhibitors of the complex, including flavaglines/rocaglates, hippuristanol, and pateamine A. Clin Cancer Res; 23(1); 21-25. ©2016 AACR.

Domaines

Cancer

Dates et versions

hal-03533702 , version 1 (18-01-2022)

Identifiants

Citer

Hélène Malka-Mahieu, Michelle Newman, Laurent Désaubry, Caroline Robert, Stéphan Vagner. Molecular Pathways: The eIF4F Translation Initiation Complex—New Opportunities for Cancer Treatment. Clinical Cancer Research, 2017, 23 (1), pp.21-25. ⟨10.1158/1078-0432.CCR-14-2362⟩. ⟨hal-03533702⟩
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