Article Dans Une Revue Molecules Année : 2024

Strategies for Accessing cis-1-Amino-2-Indanol

Stéphane Gastaldi
Jean-Simon Suppo
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Résumé

cis-1-amino-2-indanol is an important building block in many areas of chemistry. Indeed, this molecule is currently used as skeleton in many ligands (BOX, PyBOX…), catalysts and chiral auxiliaries. Moreover, it has been incorporated in numerous bioactive structures. The major issues during its synthesis are the control of cis-selectivity, for which various strategies have been devised, and the enantioselectivity of the reaction. This review highlights the various methodologies implemented over the last few decades to access cis-1-amino-2-indanol in racemic and enantioselective manners. In addition, the various substitution patterns on the aromatic ring and their preparations are listed.
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Dates et versions

hal-04589505 , version 1 (27-05-2024)

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Inès Mendas, Stéphane Gastaldi, Jean-Simon Suppo. Strategies for Accessing cis-1-Amino-2-Indanol. Molecules, 2024, 29 (11), pp.2442. ⟨10.3390/molecules29112442⟩. ⟨hal-04589505⟩
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