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Article Dans Une Revue Methods in Molecular Biology Année : 2022

Evaluation of Amyloid Inhibitor Efficiency to Block Bacterial Survival

Résumé

Amyloid inhibitors, such as the green tea compound epigallocatechin gallate EGCG, apomorphine or curlicide, have antibacterial properties. Conversely, antibiotics such as tetracycline derivatives or rifampicin also affect eukaryotic amyloids formation and may be used to treat neurodegenerative diseases. This opens the possibility for existing drugs to be repurposed in view of new therapy, targeting amyloid-like proteins from eukaryotes to prokaryotes and conversely. Here we present how to evaluate the effect of these amyloid-forming inhibitors on bacterial amyloid self-assemblies in vitro and on bacterial survival. The different approaches possible are presented.
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Dates et versions

hal-04281634 , version 1 (13-11-2023)

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Florent Busi, Florian Turbant, Jehan Waeytens, Omar El Hamoui, Frank Wien, et al.. Evaluation of Amyloid Inhibitor Efficiency to Block Bacterial Survival. Methods in Molecular Biology, 2022, 2538, pp.145--163. ⟨10.1007/978-1-0716-2529-3_11⟩. ⟨hal-04281634⟩
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